A developmentally regulated deletion element with long terminal repeats has cis-acting sequences in the flanking DNA
نویسندگان
چکیده
منابع مشابه
A developmentally regulated deletion element with long terminal repeats has cis-acting sequences in the flanking DNA.
Approximately 6000 specific DNA deletion events occur during development of the somatic macro-nucleus of the ciliate Tetrahymena. The eliminated Tlr1 element is 13 kb or more in length and has an 825 bp inverted repeat near the rearrangement junctions. A functional analysis of the cis -acting sequences required for Tlr1 rearrangement was performed. A construct consisting of the entire inverted ...
متن کاملDevelopmentally regulated excision of a 28-base-pair sequence from the Paramecium genome requires flanking DNA.
The micronuclear DNA of Paramecium tetraurelia is estimated to contain over 50,000 short DNA elements that are precisely removed during the formation of the transcriptionally active macronucleus. Each internal eliminated sequence (IES) is bounded by 5'-TA-3' dinucleotide repeats, a feature common to some classes of DNA transposons. We have developed an in vivo assay to analyze these highly effi...
متن کاملDeletion of a GC-rich region flanking the enhancer element within the long terminal repeat sequences alters the disease specificity of Moloney murine leukemia virus.
Moloney murine leukemia virus (M-MuLV) is a replication-competent retrovirus which induces T-lymphoblastic lymphoma 2 to 4 months after inoculation. Enhancer sequences in the U3 region of the M-MuLV long terminal repeat, primarily the 75-bp tandem repeats, strongly influence the disease specificity and latency of M-MuLV. We investigated the role of GC-rich sequences downstream of the tandem rep...
متن کاملABA-regulated gene expression: cis-acting sequences and trans-acting factors.
ABA-regulated gene expression: cis-acting sequences and trans-acting factors William R. Marcotte, Jr,t Mark J. Guiltinan* and Ralph S. Quatrano Department of Biology, University of North Carolina, CB # 3280, Coker Hall, Chapel Hill, NC 27599-3280, U.S.A. 93 Introduction During plant development, phytohormones influence such diverse processes as seed maturation, germination and fruit ripening. T...
متن کاملFamily of middle repetitive DNA sequences in the mouse genome with structural features of solitary retroviral long terminal repeats.
Screening of a 129/J mouse genomic library under nonstringent hybridization conditions with a xenotropic virus-like long terminal repeat (LTR) probe revealed a family of sequences resembling insertion elements (IS) with structural features of solitary retroviral LTRs; these are called LTR-IS. They are interspersed among variable flanking regions of mouse DNA and lack any viral structural genes....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2000
ISSN: 1362-4962
DOI: 10.1093/nar/28.6.1465